Feature Context Constraint

Definition and Information Model

Warning

This data class is at a draft maturity level and may change significantly in future releases. Maturity levels are described in the GKS Maturity Model.

Computational Definition

The feature that members of this categorical variant are associated with.

Information Model

Some FeatureContextConstraint attributes are inherited from Constraint.

Field	Flags	Type	Limits	Description
type		string	1..1	MUST be “FeatureContextConstraint”
featureContext		MappableConcept	1..1	A feature identifier.

Examples

The following are example implementations of FeatureContextConstraint:

Gene: TP53

      {
         "type": "FeatureContextConstraint",
         "featureContext": {
            "id": "TP53",
            "name": "TP53",
            "conceptType": "gene",
            "primaryCoding": [
               {
                  "id": "hgnc:11998",
                  "name": "TP53",
                  "system": "https://genenames.org",
                  "code": "HGNC:11998",
                  "iris": [
                     "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998"
                  ]
               }
            ],
            "extensions": [
               {
                  "name": "cytogenetic location",
                  "value": "17p13.1"
               }
            ]
         }
      },

Gene: NRAS

      {
         "type": "FeatureContextConstraint",
         "featureContext": {
            "id": "hgnc:7989",
            "conceptType": "Gene",
            "name": "NRAS",
            "primaryCoding": {
               "id": "hgnc:7989",
               "name": "NRAS",
               "system": "https://www.genenames.org",
               "code": "HGNC:7989",
               "iris": [
                  "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989"
               ]
            }
         }
      },

Gene: BRCA2

      {
         "type": "FeatureContextConstraint",
         "featureContext": {
            "id": "hgnc:1101",
            "conceptType": "Gene",
            "name": "BRCA2",
            "primaryCoding": {
               "id": "hgnc:1101",
               "name": "BRCA2",
               "system": "https://www.genenames.org",
               "code": "HGNC:1101",
               "iris": [
                  "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1101"
               ]
            }
         }
      },

Gene: PIK3CA

      {
         "type": "FeatureContextConstraint",
         "featureContext": {
            "id": "hgnc:8975",
            "conceptType": "Gene",
            "name": "PIK3CA",
            "primaryCoding": {
               "id": "hgnc:8975",
               "system": "https://www.genenames.org",
               "code": "HGNC:8975",
               "iris": [
                  "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8975"
               ]
            }
         }
      },

Implementation Guidance